論文期刊 Past publication  

 

          (1995-2019, * corresponding author, # equal contribution)

 

1.    Sethy, B., Hsieh, C. F., Lin, T. J., Hu, P. Y., Chen, Y. L., Lin, C. Y., Tseng, S. N., Horng*, J. T., and Hsieh*, P. W. (2019) Design, Synthesis, and Biological Evaluation of Itaconic Acid Derivatives as Potential Anti-Influenza Agents. Journal of medicinal chemistry 62, 2390-2403

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2.    Tang, W. F., Huang, R. T., Chien, K. Y., Tang, P., and Horng*, J. T. (2018) Large-Scale Proteomic Identification of Targets of Cellular miR-197 Downregulated by Enterovirus A71. Journal of proteome research

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3.    Sethy, B., Hsieh, C. F., Yeh, C., Horng, J. T., and Hsieh, P. W. (2018) Design, synthesis & structure-activity relationships of a new class of antihuman enterovirus D68 & A71 agents. Future Med Chem 10, 1333-1347

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4.    Huang, C. G., Lee, L. A., Wu, Y. C., Hsiao, M. J., Horng, J. T., Kuo, R. L., Huang, C. H., Lin, Y. C., Tsao, K. C., Chen, M. C., Chen, T. C., and Shih, S. R. (2018) A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients' responses to H7N9 infection. Oncotarget 9, 14492-14508

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5.    Jheng, J. R., Lau, K. S., Lan, Y. W., and Horng, J. T. (2018) A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability. Journal of biomedical science 25, 9

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6.    Chen, S. G., Cheng, M. L., Chen, K. H., Horng, J. T., Liu, C. C., Wang, S. M., Sakurai, H., Leu, Y. L., Wang, S. D., and Ho, H. Y. (2017) Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Sci Rep 7, 935

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7.    Chang, Y. H., Lau, K. S., Kuo, R. L., and Horng*, J. T. (2017) dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication. Front Cell Infect Microbiol 7, 284

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8.    Hsieh, C. F., Chen, Y. L., Lin, C. F., Ho, J. Y., Huang, C. H., Chiu, C. H., Hsieh, P. W., and Horng*, J. T. (2016) An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro. Sci Rep 6, 36015

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9.    Lin, T. J., Lin, C. F., Chiu, C. H., Lee, M. C., and Horng*, J. T. (2016) Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang). Sci Rep 6, 27768

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10.  Ho, J. Y., Chern, J. H., Hsieh, C. F., Liu, S. T., Liu, C. J., Wang, Y. S., Kuo, T. W., Hsu, S. J., Yeh, T. K., Shih, S. R., Hsieh, P. W., and Horng*, J. T. (2016) In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71. Journal of Antimicrobial Chemotherapy (accepted), IF=5.313, PHARMACOLOGY & PHARMACY: 17/255=6.67%

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11.   Tang, W. F., Huang, R. T., Chien, K. Y., Huang, J. Y., Lau, K. S., Jheng, J. R., Chiu, C. H., Wu, T. Y., Chen, C. Y., and Horng*, J. T. (2016) Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. Journal of virology 90, 1424-1438, IF=4.439, Microbiology: 7/33=21.21%

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12.   Jheng, J. R., Wang, S. C., Jheng, C. R., and Horng*, J. T. (2015) Enterovirus 71 induces dsRNA/PKR-dependent cytoplasmic redistribution of GRP78/BiP to promote viral replication. Emerging Microbes & Infections (In press), IF=2.258, Microbiology: 72/119=60.50%

 

13.     Velu, A. B., Chen, G. W., Hsieh, P. T., Horng, J. T., Hsu, J. T., Hsieh, H. P., Chen, T. C., Weng, K. F., and Shih, S. R. (2014) BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71. Antiviral research 112, 18-25, IF=3.938, PHARMACOLOGY & PHARMACY: 42/255=16.47%​

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14.     Weng, K. F., Hung, C. T., Hsieh, P. T., Li, M. L., Chen, G. W., Kung, Y. A., Huang, P. N., Kuo, R. L., Chen, L. L., Lin, J. Y., Wang, R. Y., Chen, S. J., Tang, P., Horng, J. T., Huang, H. I., Wang, J. R., Ojcius, D. M., Brewer, G., and Shih, S. R. (2014) A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells. Nucleic acids research 42, 12789-12805, IF=9.112, BIOCHEMISTRY & MOLECULAR BIOLOGY: 20/290=6.896%

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15.     Wu, M. J., Ke, P. Y., and Horng*, J. T. (2014) RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication. Biochemical and biophysical research communications 454, 19-24, IF=2.297, BIOPHYSICS: 41/73=56.16%

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16.      Jheng, J. R., Ho, J. Y., and Horng*, J. T. (2014) ER stress, autophagy, and RNA viruses. Frontiers in microbiology 5, 388, IF=3.989, Microbiology: 27/119=22.69%

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17.      Wu, M. J., Ke, P. Y., Hsu, J. T., Yeh, C. T., and Horng*, J. T. (2014) Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction. Cellular microbiology 16, 1603-1618, IF=4.915, Microbiology: 18/119=15.13%

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18.      Ho, J. Y., Chang, H. W., Lin, C. F., Liu, C. J., Hsieh, C. F., and Horng*, J. T. (2014) Characterization of the anti-influenza activity of the Chinese herbal plant Paeonia lactiflora. Viruses 6, 1861-1875, IF=3.353, VIROLOGY: 12/33=36.36%

Chen, L. L., Kung, Y. A., Weng, K. F., Lin, J. Y., Horng, J. T., and Shih, S. R. (2013) Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation. Journal of virology 87, 3828-3838

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19.     Hsu, K. C., Hung, H. C., Horng, J. T., Fang, M. Y., Chang, C. Y., Li, L. T., Chen, I. J., Chen, Y. C., Chou, D. L., Chang, C. W., Hsieh, H. P., Yang, J. M., and Hsu, J. T. (2013) Parallel screening of wild-type and drug-resistant targets for anti-resistance neuraminidase inhibitors. PloS one 8, e56704

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20.     Mok, C. K., Chen, G. W., Shih, K. C., Gong, Y. N., Lin, S. J., Horng, J. T., Hsu, J. T., Chen, C. J., and Shih, S. R. (2013) Evolutionarily conserved residues at an oligomerization interface of the influenza A virus neuraminidase are essential for viral survival. Virology 447, 32-44

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21.     Hsieh, C. F., Yen, H. R., Liu, C. H., Lin, S., and Horng*, J. T. (2012) Ching-fang-pai-tu-san inhibits the release of influenza virus. Journal of ethnopharmacology 144, 533-544

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22.     Yeh, J. Y., Coumar, M. S., Shiao, H. Y., Lin, T. J., Lee, Y. C., Hung, H. C., Ko, S., Kuo, F. M., Fang, M. Y., Huang, Y. L., Hsu, J. T., Yeh, T. K., Shih, S. R., Chao, Y. S., Horng*, J. T., and Hsieh*, H. P. (2012) Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization. ChemMedChem 7, 1546-1550

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23.     Liu, C. H., Horng, J. T., Chang, J. S., Hsieh, C. F., Tseng, Y. C., and Lin, S. (2012) Localization and force analysis at the single virus particle level using atomic force microscopy. Biochemical and biophysical research communications 417, 109-115

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24.     Jheng, J. R., Lin, C. Y., Horng*, J. T., and Lau, K. S. (2012) Inhibition of enterovirus 71 entry by transcription factor XBP1. Biochemical and biophysical research communications 420, 882-887

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25.     Hung, H. C., Liu, C. L., Hsu, J. T., Horng, J. T., Fang, M. Y., Wu, S. Y., Ueng, S. H., Wang, M. Y., Yaw, C. W., and Hou, M. H. (2012) Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching. Analytical chemistry 84, 6391-6399

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26.     Hsieh, C. F., Lo, C. W., Liu, C. H., Lin, S., Yen, H. R., Lin, T. Y., and Horng*, J. T. (2012) Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. Journal of ethnopharmacology 143, 57-67

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27.    Chang, C. W., Leu, Y. L., and Horng*, J. T. (2012) Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. Viruses 4, 539-556

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28.     Hsu, J. T., Yeh, J. Y., Lin, T. J., Li, M. L., Wu, M. S., Hsieh, C. F., Chou, Y. C., Tang, W. F., Lau, K. S., Hung, H. C., Fang, M. Y., Ko, S., Hsieh, H. P., and Horng*, J. T. (2012) Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus. Antimicrob Agents Chemother 56, 647-657

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29.    Wu, M. S., Yen, H. R., Chang, C. W., Peng, T. Y., Hsieh, C. F., Chen, C. J., Lin, T. Y., and Horng*, J. T. (2011) Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. Journal of ethnopharmacology 134, 614-623

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30.    Shih, S. R., Chu, T. Y., Reddy, G. R., Tseng, S. N., Chen, H. L., Tang, W. F., Wu, M. S., Yeh, J. Y., Chao, Y. S., Hsu, J. T., Hsieh, H. P., and Horng*, J. T. (2010) Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity. Journal of biomedical science 17, 13

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31.    Yeh#, J. Y., Coumar#, M. S., Horng#, J. T., Shiao, H. Y., Kuo, F. M., Lee, H. L., Chen, I. C., Chang, C. W., Tang, W. F., Tseng, S. N., Chen, C. J., Shih, S. R., Hsu, J. T., Liao, C. C., Chao, Y. S., and Hsieh, H. P. (2010) Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives. Journal of medicinal chemistry 53, 1519-1533

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32.    Lin#, C. S., Horng#, J. T., Yang, C. H., Tsai, Y. H., Su, L. H., Wei, C. F., Chen, C. C., Hsieh, S. C., Lu, C. C., and Lai, H. C. (2010) RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens. Infection and immunity 78, 4870-4881

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33.    Shih#, S. R., Horng#, J. T., Poon, L. L., Chen, T. C., Yeh, J. Y., Hsieh, H. P., Tseng, S. N., Chiang, C., Li, W. L., Chao, Y. S., and Hsu, J. T. (2010) BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses. The Journal of antimicrobial chemotherapy 65, 63-71

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34.    Jheng, J. R., Lau, K. S., Tang, W. F., Wu, M. S., and Horng*, J. T. (2010) Endoplasmic reticulum stress is induced and modulated by enterovirus 71. Cellular microbiology 12, 796-813

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35.    Lin, T. Y., Liu, Y. C., Jheng, J. R., Tsai, H. P., Jan, J. T., Wong, W. R., and Horng*, J. T. (2009) Anti-enterovirus 71 activity screening of chinese herbs with anti-infection and inflammation activities. The American journal of Chinese medicine 37, 143-158

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36.    Lin, J. Y., Li, M. L., Huang, P. N., Chien, K. Y., Horng, J. T., and Shih, S. R. (2008) Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication. The Journal of general virology 89, 2540-2549

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37.    Chen, Y. J., Zeng, S. J., Hsu, J. T., Horng, J. T., Yang, H. M., Shih, S. R., Chu, Y. T., and Wu, T. Y. (2008) Amantadine as a regulator of internal ribosome entry site. Acta pharmacologica Sinica 29, 1327-1333

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38.  Wu, B. W., Pan, T. L., Leu, Y. L., Chang, Y. K., Tai, P. J., Lin, K. H., and Horng*, J. T. (2007) Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71. The American journal of Chinese medicine 35, 153-168

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39.    Tung, W. H., Sun, C. C., Hsieh, H. L., Wang, S. W., Horng, J. T., and Yang, C. M. (2007) EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK, JNK and NF-kappaB in vascular smooth muscle cells. Cellular signalling 19, 2127-2137

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40.    Tang, W. F., Yang, S. Y., Wu, B. W., Jheng, J. R., Chen, Y. L., Shih, C. H., Lin, K. H., Lai, H. C., Tang, P., and Horng*, J. T. (2007) Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. The Journal of biological chemistry 282, 5888-5898

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41.    Wei, J. R., Tsai, Y. H., Horng, Y. T., Soo, P. C., Hsieh, S. C., Hsueh, P. R., Horng, J. T., Williams, P., and Lai, H. C. (2006) A mobile quorum-sensing system in Serratia marcescens. Journal of bacteriology 188, 1518-1525

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42.    Chang, Y. K., Horng, J. T., Huang, R. Z., and Lin, S. Y. (2006) Direct capture of factor IX from unclarified human plasma by IMEBAC. Biochemical Engineering Journal 29, 12-22

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43.    Chang, Y. K., Horng, J. T., Huang, R. Z., and Lin, S. Y. (2006) Direct recovery of clotting factor IX from unclarified human plasma by expanded bed ion exchange chromatography. Biochemical Engineering Journal 30, 138-146

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44.    Wong, W. R., Chen, Y. Y., Yang, S. M., Chen, Y. L., and Horng*, J. T. (2005) Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71. Life sciences 78, 82-90

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45.    Horng*, J. T., and Tan, C. Y. (2004) Biochemical characterization of the coating mechanism of the endosomal donor compartment of synaptic vesicles. Neurochemical research 29, 1411-1416

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46.    Salem, N., Faundez, V., Horng, J. T., and Kelly, R. B. (1998) A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex. Nature neuroscience 1, 551-556

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47.    Pool, M. R., Lopez-Huertas, E., Horng, J. T., and Baker, A. (1998) NADPH is a specific inhibitor of protein import into glyoxysomes. Plant J 15, 1-14

31.    Faundez#, V., Horng#, J. T., and Kelly, R. B. (1998) A function for the AP3 coat complex in synaptic vesicle formation from endosomes. Cell 93, 423-432

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48.    Clift-O'Grady, L., Desnos, C., Lichtenstein, Y., Faundez, V., Horng, J. T., and Kelly, R. B. (1998) Reconstitution of synaptic vesicle biogenesis from PC12 cell membranes. Methods (San Diego, Calif 16, 150-159

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49.    Faundez, V., Horng, J. T., and Kelly, R. B. (1997) ADP ribosylation factor 1 is required for synaptic vesicle budding in PC12 cells. The Journal of cell biology 138, 505-515

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50.    Horng, J. T., Behari, R., Burke, L. E., and Baker, A. (1995) Investigation of the energy requirement and targeting signal for the import of glycolate oxidase into glyoxysomes. European journal of biochemistry / FEBS 230, 157-163