論文期刊 Past publication  

 

          (1995-2019, * corresponding author, # equal contribution)

 

1.    Sethy, B., Hsieh, C. F., Lin, T. J., Hu, P. Y., Chen, Y. L., Lin, C. Y., Tseng, S. N., Horng*, J. T., and Hsieh*, P. W. (2019) Design, Synthesis, and Biological Evaluation of Itaconic Acid Derivatives as Potential Anti-Influenza Agents. Journal of medicinal chemistry 62, 2390-2403

2.    Tang, W. F., Huang, R. T., Chien, K. Y., Tang, P., and Horng*, J. T. (2018) Large-Scale Proteomic Identification of Targets of Cellular miR-197 Downregulated by Enterovirus A71. Journal of proteome research

3.    Sethy, B., Hsieh, C. F., Yeh, C., Horng, J. T., and Hsieh, P. W. (2018) Design, synthesis & structure-activity relationships of a new class of antihuman enterovirus D68 & A71 agents. Future Med Chem 10, 1333-1347

4.    Huang, C. G., Lee, L. A., Wu, Y. C., Hsiao, M. J., Horng, J. T., Kuo, R. L., Huang, C. H., Lin, Y. C., Tsao, K. C., Chen, M. C., Chen, T. C., and Shih, S. R. (2018) A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients' responses to H7N9 infection. Oncotarget 9, 14492-14508

5.    Jheng, J. R., Lau, K. S., Lan, Y. W., and Horng, J. T. (2018) A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability. Journal of biomedical science 25, 9

6.    Chen, S. G., Cheng, M. L., Chen, K. H., Horng, J. T., Liu, C. C., Wang, S. M., Sakurai, H., Leu, Y. L., Wang, S. D., and Ho, H. Y. (2017) Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Sci Rep 7, 935

7.    Chang, Y. H., Lau, K. S., Kuo, R. L., and Horng*, J. T. (2017) dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication. Front Cell Infect Microbiol 7, 284

8.    Hsieh, C. F., Chen, Y. L., Lin, C. F., Ho, J. Y., Huang, C. H., Chiu, C. H., Hsieh, P. W., and Horng*, J. T. (2016) An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro. Sci Rep 6, 36015

9.    Lin, T. J., Lin, C. F., Chiu, C. H., Lee, M. C., and Horng*, J. T. (2016) Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang). Sci Rep 6, 27768

10.  Ho, J. Y., Chern, J. H., Hsieh, C. F., Liu, S. T., Liu, C. J., Wang, Y. S., Kuo, T. W., Hsu, S. J., Yeh, T. K., Shih, S. R., Hsieh, P. W., and Horng*, J. T. (2016) In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71. Journal of Antimicrobial Chemotherapy (accepted), IF=5.313, PHARMACOLOGY & PHARMACY: 17/255=6.67%

11.   Tang, W. F., Huang, R. T., Chien, K. Y., Huang, J. Y., Lau, K. S., Jheng, J. R., Chiu, C. H., Wu, T. Y., Chen, C. Y., and Horng*, J. T. (2016) Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. Journal of virology 90, 1424-1438, IF=4.439, Microbiology: 7/33=21.21%

12.   Jheng, J. R., Wang, S. C., Jheng, C. R., and Horng*, J. T. (2015) Enterovirus 71 induces dsRNA/PKR-dependent cytoplasmic redistribution of GRP78/BiP to promote viral replication. Emerging Microbes & Infections (In press), IF=2.258, Microbiology: 72/119=60.50%

 

13.     Velu, A. B., Chen, G. W., Hsieh, P. T., Horng, J. T., Hsu, J. T., Hsieh, H. P., Chen, T. C., Weng, K. F., and Shih, S. R. (2014) BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71. Antiviral research 112, 18-25, IF=3.938, PHARMACOLOGY & PHARMACY: 42/255=16.47%

14.     Weng, K. F., Hung, C. T., Hsieh, P. T., Li, M. L., Chen, G. W., Kung, Y. A., Huang, P. N., Kuo, R. L., Chen, L. L., Lin, J. Y., Wang, R. Y., Chen, S. J., Tang, P., Horng, J. T., Huang, H. I., Wang, J. R., Ojcius, D. M., Brewer, G., and Shih, S. R. (2014) A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells. Nucleic acids research 42, 12789-12805, IF=9.112, BIOCHEMISTRY & MOLECULAR BIOLOGY: 20/290=6.896%

15.     Wu, M. J., Ke, P. Y., and Horng*, J. T. (2014) RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication. Biochemical and biophysical research communications 454, 19-24, IF=2.297, BIOPHYSICS: 41/73=56.16%

16.      Jheng, J. R., Ho, J. Y., and Horng*, J. T. (2014) ER stress, autophagy, and RNA viruses. Frontiers in microbiology 5, 388, IF=3.989, Microbiology: 27/119=22.69%

17.      Wu, M. J., Ke, P. Y., Hsu, J. T., Yeh, C. T., and Horng*, J. T. (2014) Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction. Cellular microbiology 16, 1603-1618, IF=4.915, Microbiology: 18/119=15.13%

18.      Ho, J. Y., Chang, H. W., Lin, C. F., Liu, C. J., Hsieh, C. F., and Horng*, J. T. (2014) Characterization of the anti-influenza activity of the Chinese herbal plant Paeonia lactiflora. Viruses 6, 1861-1875, IF=3.353, VIROLOGY: 12/33=36.36%

Chen, L. L., Kung, Y. A., Weng, K. F., Lin, J. Y., Horng, J. T., and Shih, S. R. (2013) Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation. Journal of virology 87, 3828-3838

19.     Hsu, K. C., Hung, H. C., Horng, J. T., Fang, M. Y., Chang, C. Y., Li, L. T., Chen, I. J., Chen, Y. C., Chou, D. L., Chang, C. W., Hsieh, H. P., Yang, J. M., and Hsu, J. T. (2013) Parallel screening of wild-type and drug-resistant targets for anti-resistance neuraminidase inhibitors. PloS one 8, e56704

20.     Mok, C. K., Chen, G. W., Shih, K. C., Gong, Y. N., Lin, S. J., Horng, J. T., Hsu, J. T., Chen, C. J., and Shih, S. R. (2013) Evolutionarily conserved residues at an oligomerization interface of the influenza A virus neuraminidase are essential for viral survival. Virology 447, 32-44

21.     Hsieh, C. F., Yen, H. R., Liu, C. H., Lin, S., and Horng*, J. T. (2012) Ching-fang-pai-tu-san inhibits the release of influenza virus. Journal of ethnopharmacology 144, 533-544

22.     Yeh, J. Y., Coumar, M. S., Shiao, H. Y., Lin, T. J., Lee, Y. C., Hung, H. C., Ko, S., Kuo, F. M., Fang, M. Y., Huang, Y. L., Hsu, J. T., Yeh, T. K., Shih, S. R., Chao, Y. S., Horng*, J. T., and Hsieh*, H. P. (2012) Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization. ChemMedChem 7, 1546-1550

23.     Liu, C. H., Horng, J. T., Chang, J. S., Hsieh, C. F., Tseng, Y. C., and Lin, S. (2012) Localization and force analysis at the single virus particle level using atomic force microscopy. Biochemical and biophysical research communications 417, 109-115

24.     Jheng, J. R., Lin, C. Y., Horng*, J. T., and Lau, K. S. (2012) Inhibition of enterovirus 71 entry by transcription factor XBP1. Biochemical and biophysical research communications 420, 882-887

25.     Hung, H. C., Liu, C. L., Hsu, J. T., Horng, J. T., Fang, M. Y., Wu, S. Y., Ueng, S. H., Wang, M. Y., Yaw, C. W., and Hou, M. H. (2012) Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching. Analytical chemistry 84, 6391-6399

26.     Hsieh, C. F., Lo, C. W., Liu, C. H., Lin, S., Yen, H. R., Lin, T. Y., and Horng*, J. T. (2012) Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. Journal of ethnopharmacology 143, 57-67

27.    Chang, C. W., Leu, Y. L., and Horng*, J. T. (2012) Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. Viruses 4, 539-556

28.     Hsu, J. T., Yeh, J. Y., Lin, T. J., Li, M. L., Wu, M. S., Hsieh, C. F., Chou, Y. C., Tang, W. F., Lau, K. S., Hung, H. C., Fang, M. Y., Ko, S., Hsieh, H. P., and Horng*, J. T. (2012) Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus. Antimicrob Agents Chemother 56, 647-657

29.    Wu, M. S., Yen, H. R., Chang, C. W., Peng, T. Y., Hsieh, C. F., Chen, C. J., Lin, T. Y., and Horng*, J. T. (2011) Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. Journal of ethnopharmacology 134, 614-623

30.    Shih, S. R., Chu, T. Y., Reddy, G. R., Tseng, S. N., Chen, H. L., Tang, W. F., Wu, M. S., Yeh, J. Y., Chao, Y. S., Hsu, J. T., Hsieh, H. P., and Horng*, J. T. (2010) Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity. Journal of biomedical science 17, 13

31.    Yeh#, J. Y., Coumar#, M. S., Horng#, J. T., Shiao, H. Y., Kuo, F. M., Lee, H. L., Chen, I. C., Chang, C. W., Tang, W. F., Tseng, S. N., Chen, C. J., Shih, S. R., Hsu, J. T., Liao, C. C., Chao, Y. S., and Hsieh, H. P. (2010) Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives. Journal of medicinal chemistry 53, 1519-1533

32.    Lin#, C. S., Horng#, J. T., Yang, C. H., Tsai, Y. H., Su, L. H., Wei, C. F., Chen, C. C., Hsieh, S. C., Lu, C. C., and Lai, H. C. (2010) RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens. Infection and immunity 78, 4870-4881

33.    Shih#, S. R., Horng#, J. T., Poon, L. L., Chen, T. C., Yeh, J. Y., Hsieh, H. P., Tseng, S. N., Chiang, C., Li, W. L., Chao, Y. S., and Hsu, J. T. (2010) BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses. The Journal of antimicrobial chemotherapy 65, 63-71

34.    Jheng, J. R., Lau, K. S., Tang, W. F., Wu, M. S., and Horng*, J. T. (2010) Endoplasmic reticulum stress is induced and modulated by enterovirus 71. Cellular microbiology 12, 796-813

35.    Lin, T. Y., Liu, Y. C., Jheng, J. R., Tsai, H. P., Jan, J. T., Wong, W. R., and Horng*, J. T. (2009) Anti-enterovirus 71 activity screening of chinese herbs with anti-infection and inflammation activities. The American journal of Chinese medicine 37, 143-158

36.    Lin, J. Y., Li, M. L., Huang, P. N., Chien, K. Y., Horng, J. T., and Shih, S. R. (2008) Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication. The Journal of general virology 89, 2540-2549

37.    Chen, Y. J., Zeng, S. J., Hsu, J. T., Horng, J. T., Yang, H. M., Shih, S. R., Chu, Y. T., and Wu, T. Y. (2008) Amantadine as a regulator of internal ribosome entry site. Acta pharmacologica Sinica 29, 1327-1333

38.  Wu, B. W., Pan, T. L., Leu, Y. L., Chang, Y. K., Tai, P. J., Lin, K. H., and Horng*, J. T. (2007) Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71. The American journal of Chinese medicine 35, 153-168

39.    Tung, W. H., Sun, C. C., Hsieh, H. L., Wang, S. W., Horng, J. T., and Yang, C. M. (2007) EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK, JNK and NF-kappaB in vascular smooth muscle cells. Cellular signalling 19, 2127-2137

40.    Tang, W. F., Yang, S. Y., Wu, B. W., Jheng, J. R., Chen, Y. L., Shih, C. H., Lin, K. H., Lai, H. C., Tang, P., and Horng*, J. T. (2007) Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. The Journal of biological chemistry 282, 5888-5898

41.    Wei, J. R., Tsai, Y. H., Horng, Y. T., Soo, P. C., Hsieh, S. C., Hsueh, P. R., Horng, J. T., Williams, P., and Lai, H. C. (2006) A mobile quorum-sensing system in Serratia marcescens. Journal of bacteriology 188, 1518-1525

42.    Chang, Y. K., Horng, J. T., Huang, R. Z., and Lin, S. Y. (2006) Direct capture of factor IX from unclarified human plasma by IMEBAC. Biochemical Engineering Journal 29, 12-22

43.    Chang, Y. K., Horng, J. T., Huang, R. Z., and Lin, S. Y. (2006) Direct recovery of clotting factor IX from unclarified human plasma by expanded bed ion exchange chromatography. Biochemical Engineering Journal 30, 138-146

44.    Wong, W. R., Chen, Y. Y., Yang, S. M., Chen, Y. L., and Horng*, J. T. (2005) Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71. Life sciences 78, 82-90

45.    Horng*, J. T., and Tan, C. Y. (2004) Biochemical characterization of the coating mechanism of the endosomal donor compartment of synaptic vesicles. Neurochemical research 29, 1411-1416

46.    Salem, N., Faundez, V., Horng, J. T., and Kelly, R. B. (1998) A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex. Nature neuroscience 1, 551-556

47.    Pool, M. R., Lopez-Huertas, E., Horng, J. T., and Baker, A. (1998) NADPH is a specific inhibitor of protein import into glyoxysomes. Plant J 15, 1-14

31.    Faundez#, V., Horng#, J. T., and Kelly, R. B. (1998) A function for the AP3 coat complex in synaptic vesicle formation from endosomes. Cell 93, 423-432

48.    Clift-O'Grady, L., Desnos, C., Lichtenstein, Y., Faundez, V., Horng, J. T., and Kelly, R. B. (1998) Reconstitution of synaptic vesicle biogenesis from PC12 cell membranes. Methods (San Diego, Calif 16, 150-159

49.    Faundez, V., Horng, J. T., and Kelly, R. B. (1997) ADP ribosylation factor 1 is required for synaptic vesicle budding in PC12 cells. The Journal of cell biology 138, 505-515

50.    Horng, J. T., Behari, R., Burke, L. E., and Baker, A. (1995) Investigation of the energy requirement and targeting signal for the import of glycolate oxidase into glyoxysomes. European journal of biochemistry / FEBS 230, 157-163

33302桃園市龜山區文化一路259號長庚大學

            第一醫學大樓生化科0866室

電話:03-2118800#5156

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Department of Biochemistry & Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, 33302, Taiwan.

Office: 886-3-211-8800#5156

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